Genetic risk of Parkinson disease and progression:
نویسندگان
چکیده
منابع مشابه
Identification of Genetic Risk Factors for Parkinson Disease : Association Studies
Recent findings Mutations in VPS35 were identified as a novel cause of autosomal dominant Parkinson disease using exome sequencing. Next generation sequencing (NGS) was also used to identify PRRT2 mutations as a cause of paroxysmal kinesigenic dyskinesia (DYT10). Using a different technique, that is linkage analysis, mutations in EIF4G1 were implicated as a cause of Parkinson disease and mutati...
متن کاملProgression of parkinsonian signs in Parkinson disease.
BACKGROUND Current knowledge about the rate of progression of extrapyramidal signs (EPSs) in Parkinson disease (PD) is derived largely from cross-sectional studies comparing subjects at various stages of illness rather than longitudinal studies in which the subjects were followed up over time. OBJECTIVE To longitudinally study the progression of EPSs in PD by quantifying the rate of change of...
متن کاملGenetic heterogeneity in Parkinson disease
Neurology 2012;79:619–620 Parkinson disease (PD) is considered a sporadic neurodegenerative disorder, though genetic factors are frequently involved in its etiology. That some familial presentations of PD have been associated with different mutated genes suggests that some genetic variants can also modulate the risk for “nonfamilial” presentation of PD. The hypothesis-free genomewide associatio...
متن کاملIncidence, Risk and Prognosis of Parkinson Disease
Background Parkinson disease is the second most common neurodegenerative disease and the proportion of people suffering from parkinsonism and Parkinson disease is expected to increase as populations age. Few studies investigated the incidence of parkinsonism and Parkinson disease in the general population, and most of these were based on clinical data only. Objective To estimate the incidence o...
متن کاملthe study of practical and theoretical foundation of credit risk and its coverage
پس از بررسی هر کدام از فاکتورهای نوع صنعت, نوع ضمانت نامه, نرخ بهره , نرخ تورم, ریسک اعتباری کشورها, کارمزد, ریکاوری, gdp, پوشش و وثیقه بر ریسک اعتباری صندوق ضمانت صادرات ایران مشخص گردید که همه فاکتورها به استثنای ریسک اعتباری کشورها و کارمزد بقیه فاکتورها رابطه معناداری با ریسک اعتباری دارند در ضمن نرخ بهره , نرخ تورم, ریکاوری, و نوع صنعت و ریسک کشورها اثر عکس روی ریسک اعتباری داردو پوشش, وثی...
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ژورنال
عنوان ژورنال: Neurology Genetics
سال: 2019
ISSN: 2376-7839
DOI: 10.1212/nxg.0000000000000348